1-(2-联苯基)哌嗪
化合物
1-(2-联苯基)哌嗪是一种有机化合物，化学式为C16H18N2。它可由1-叔丁氧羰基-4-(2-溴苯基)哌嗪和苯硼酸在四(三苯基膦)钯催化下反应制得，[1]或由2-氨基联苯和二(氯乙基)胺盐酸盐在碳酸钾和碘化钾存在下反应得到。[2]它和N-苄基-6-溴己酰胺在碳酸钾存在下于乙腈中回流反应，可以得到N-苄基-(4-联苯-2-基)哌嗪己酰胺。[3]
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| CAS号 | 180698-18-4  |
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| 化学信息 | |
| 化学式 | C16H18N2 |
| 摩尔质量 | 238.33 g·mol−1 |
| 3D模型（JSmol） | |
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参考文献
- ^ Yu, Maolin; Daniels, Matthew H.; Harmange, Jean-Christophe P.; Tibbitts, Thomas T.; Ledeboer, Mark W.; Walsh, Liron; Mundel, Peter H.; Malojcic, Goran. Pyridazinone derivatives in the treatment of disease and their preparation. 2019 WO 2019055966 A2.
- ^ Stefania Porcu, Stefania Demuro, Alberto Luridiana, Andrea Cocco, Angelo Frongia, David J. Aitken, Florence Charnay-Pouget, Regis Guillot, Giorgia Sarais, Francesco Secci. Brønsted Acid Mediated Cascade Reaction To Access 3-(2-Bromoethyl)benzofurans. Organic Letters. 2018-12-07, 20 (23): 7699–7702 [2022-03-05]. ISSN 1523-7060. doi:10.1021/acs.orglett.8b03429. （原始内容存档于2022-03-05） （英语）.
- ^ Marcello Leopoldo, Enza Lacivita, Paola De Giorgio, Claudia Fracasso, Sara Guzzetti, Silvio Caccia, Marialessandra Contino, Nicola A. Colabufo, Francesco Berardi, Roberto Perrone. Structural Modifications of N -(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-Aryl-1-piperazinehexanamides: Influence on Lipophilicity and 5-HT 7 Receptor Activity. Part III. Journal of Medicinal Chemistry. 2008-09-25, 51 (18): 5813–5822 [2022-03-05]. ISSN 0022-2623. doi:10.1021/jm800615e. （原始内容存档于2022-03-05） （英语）.