西那西呱

西那西呱
臨床資料
给药途径	静脉注射 (?)
ATC碼	未分配;
识别信息
	IUPAC命名法 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl); phenyl]methoxy}phenyl)ethyl]amino}methyl); benzoic acid; ;
CAS号	329773-35-5
PubChem CID	9808022;
IUPHAR/BPS	5168;
ChemSpider	7983781 ;
UNII	59K0Y58UAD;
ChEBI	CHEBI:142433;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID40954614 ;
化学信息
化学式	C36H39NO5
摩尔质量	565.71 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES c4ccccc4CCc3ccc(cc3)COc1ccccc1CCN(CCCCC(O)=O)Cc2ccc(C(=O)O)cc2;
	InChI InChI=1S/C36H39NO5/c38-35(39)12-6-7-24-37(26-30-19-21-33(22-20-30)36(40)41)25-23-32-10-4-5-11-34(32)42-27-31-17-15-29(16-18-31)14-13-28-8-2-1-3-9-28/h1-5,8-11,15-22H,6-7,12-14,23-27H2,(H,38,39)(H,40,41) ; Key:WPYWMXNXEZFMAK-UHFFFAOYSA-N ;

西那西呱（INN：cinaciguat；开发代号：BAY 58-2667）是一种实验性可溶性鸟苷酸环化酶（英语：Soluble guanylyl cyclase）激活剂，设计用于治疗急性失代偿性心力衰竭（英语：Acute decompensated heart failure）。^[1]^[2]该药物能提高环磷酸鸟苷的产量进而引起肺血管舒张。^[3]^[4]

参考资料

^ Gheorghiade, Mihai; Greene, Stephen J.; Filippatos, Gerasimos; Erdmann, Erland; Ferrari, Roberto; Levy, Phillip D.; Maggioni, Aldo; Nowack, Christina; Mebazaa, Alexandre; COMPOSE Investigators and Coordinators. Cinaciguat, a soluble guanylate cyclase activator: results from the randomized, controlled, phase IIb COMPOSE programme in acute heart failure syndromes. European Journal of Heart Failure. 2012-09, 14 (9). ISSN 1879-0844. PMID 22713287. doi:10.1093/eurjhf/hfs093.
^ Erdmann, Erland; Semigran, Marc J.; Nieminen, Markku S.; Gheorghiade, Mihai; Agrawal, Rahul; Mitrovic, Veselin; Mebazaa, Alexandre. Cinaciguat, a soluble guanylate cyclase activator, unloads the heart but also causes hypotension in acute decompensated heart failure. European Heart Journal. 2013-01, 34 (1). ISSN 1522-9645. PMID 22778174. doi:10.1093/eurheartj/ehs196.
^ Chester, Marc; Seedorf, Gregory; Tourneux, Pierre; Gien, Jason; Tseng, Nancy; Grover, Theresa; Wright, Jason; Stasch, Johannes-Peter; Abman, Steven H. Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension. American Journal of Physiology. Lung Cellular and Molecular Physiology. 2011-11, 301 (5). ISSN 1522-1504. PMC 3213988  . PMID 21856817. doi:10.1152/ajplung.00138.2010.
^ Chester, Marc; Tourneux, Pierre; Seedorf, Greg; Grover, Theresa R.; Gien, Jason; Abman, Steven H. Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus. American Journal of Physiology. Lung Cellular and Molecular Physiology. 2009-08, 297 (2). ISSN 1522-1504. PMC 2742799  . PMID 19465519. doi:10.1152/ajplung.00062.2009.

[pmid22713287-1] Gheorghiade, Mihai; Greene, Stephen J.; Filippatos, Gerasimos; Erdmann, Erland; Ferrari, Roberto; Levy, Phillip D.; Maggioni, Aldo; Nowack, Christina; Mebazaa, Alexandre; COMPOSE Investigators and Coordinators. Cinaciguat, a soluble guanylate cyclase activator: results from the randomized, controlled, phase IIb COMPOSE programme in acute heart failure syndromes. European Journal of Heart Failure. 2012-09, 14 (9). ISSN 1879-0844. PMID 22713287. doi:10.1093/eurjhf/hfs093.

[pmid22778174-2] Erdmann, Erland; Semigran, Marc J.; Nieminen, Markku S.; Gheorghiade, Mihai; Agrawal, Rahul; Mitrovic, Veselin; Mebazaa, Alexandre. Cinaciguat, a soluble guanylate cyclase activator, unloads the heart but also causes hypotension in acute decompensated heart failure. European Heart Journal. 2013-01, 34 (1). ISSN 1522-9645. PMID 22778174. doi:10.1093/eurheartj/ehs196.

[pmid21856817-3] Chester, Marc; Seedorf, Gregory; Tourneux, Pierre; Gien, Jason; Tseng, Nancy; Grover, Theresa; Wright, Jason; Stasch, Johannes-Peter; Abman, Steven H. Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension. American Journal of Physiology. Lung Cellular and Molecular Physiology. 2011-11, 301 (5). ISSN 1522-1504. PMC 3213988  . PMID 21856817. doi:10.1152/ajplung.00138.2010.

[pmid19465519-4] Chester, Marc; Tourneux, Pierre; Seedorf, Greg; Grover, Theresa R.; Gien, Jason; Abman, Steven H. Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus. American Journal of Physiology. Lung Cellular and Molecular Physiology. 2009-08, 297 (2). ISSN 1522-1504. PMC 2742799  . PMID 19465519. doi:10.1152/ajplung.00062.2009.

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