药物敏化
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药物敏化（英語：drug sensitization），也称逆耐药性（英語：reverse tolerance），是指在耐药性已经确立后，不敏感度的减少。[5][6]一般来说，这种现象是由于加药、停药（用药假期）导致。苯丙胺和选择性5-羟色胺再摄取抑制剂（SSRI）等药物都会引发药物敏化的情况。[7][8]
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参考资料
- ^ Nestler, Eric J.; Malenka, Robert C. Chapter 15: Reinforcement and Addictive Disorders. Molecular neuropharmacology : a foundation for clinical neuroscience 2nd. New York: McGraw-Hill Medical. 2009: 364–375. ISBN 978-0-07-164119-7. OCLC 273018757.
- ^ Nestler, Eric J. Cellular basis of memory for addiction. Dialogues in Clinical Neuroscience. 2013-12, 15 (4): 431–443. ISSN 1294-8322. PMC 3898681
. PMID 24459410. doi:10.31887/DCNS.2013.15.4/enestler.
- ^ Glossary. Icahn School of Medicine. [2021-04-29].
- ^ Volkow, Nora D.; Koob, George F.; McLellan, A. Thomas. Longo, Dan L. , 编. Neurobiologic Advances from the Brain Disease Model of Addiction. New England Journal of Medicine. 2016-01-28, 374 (4): 363–371. ISSN 0028-4793. PMC 6135257 . PMID 26816013. doi:10.1056/NEJMra1511480 （英语）.
- ^ Hijikuro K, Kaneto H. Cross reverse tolerance between amphetamine, cocaine and morphine. J Pharmacobiodyn: 503–5. PMID 3437393. doi:10.1248/bpb1978.10.503.
- ^ Drugs & Death : Profiles of illegal drug abuse. Joseph C. Rupp, M.D., Ph.D. 互联网档案馆的存檔，存档日期2008-12-18.
- ^ Leith N, Kuczenski R. Chronic amphetamine: tolerance and reverse tolerance reflect different behavioral actions of the drug.. Pharmacol Biochem Behav. 1981, 15 (3): 399–404. PMID 7291243. doi:10.1016/0091-3057(81)90269-0.
- ^ Chaudhry I, Turkanis S, Karler R. Characteristics of "reverse tolerance" to amphetamine-induced locomotor stimulation in mice.. Neuropharmacology. 1988, 27 (8): 777–81. PMID 3216957. doi:10.1016/0028-3908(88)90091-3.
