英矽智能

英矽智能[註 1](英語:Insilico Medicine),是一家美國生物科技公司,總部座落於香港科學園和紐約 The Cure 大樓。英矽智能結合基因體學大數據分析以及深度學習來進行電腦藥物開發。[2][3][4]

英矽智能
原文名称Insilico Medicine
公司類型私營企業
成立2014年 (2014)[1]
創辦人阿歷克斯·查沃隆科夫(Alex Zhavoronkov
總部香港;紐約
产业生物技术
服務
网站insilicomedicine.com

歷史

執行長亞歷克斯-扎沃洛科夫(Alex Zhavoronkov)於2014年創立英矽智能,致力於發展替代方案來取代藥廠裡藥物研發中的動物實驗。藉由人工智慧以及深度學習技術,英矽智能的AI引擎能夠分析藥物如何作用於細胞以及可能的副作用。透過Pharma.AI,英矽智能提供機器學習的服務給數家知名藥廠、生物科技公司以及化妝品公司。[5][6] 英矽智能亦聞名於透過自行創建的分子線上黑客松來招募所需人才。[7]

英矽智能有許多的合作案應用次世代的人工智慧技術例如生成對抗網路(GANs)和強化學習(RL)來產生具有理想特性的新穎分子結構。[8][9]透過和美國哈佛大學教授Alan Aspuru-Guzik研究團隊合作,他們發表了更好的生成對抗性網路架構,結合生成對抗網路強化學習以及可微神經電腦(DNC)來產生新的分子結構。[10]

英矽智能最近和11個不同的研究機構共同發表在自然通訊的論文提出iPANDA降維演算法, [11] 此外英矽智能也和生物科技公司以外的單位合作發表論文專注在組織多樣性以及反種族歧視。[12] 英矽智能並和葛蘭素史克 [13] Bio Time,[14] Juvenescence,[15] 和量子電腦公司 YMK Photonics是合作夥伴。[16]

2017年,英矽智能當選[輝達 輝達](NVIDIA)五大“潛在最具社會影響力AI公司“之一, [17] 英矽智能在比利時、俄羅斯和英國設有研發中心,並透過各個程式設計黑客松比賽來聘僱人才。[18] 至2017年為止,英矽智能從投資者募資到$8.26百萬美金,其中包括Deep Knowledge Venture 、JHU A-Level Capital, [19]Jim Mellon, [20]and Juvenescence。[21][22][23][1] 在2018年公佈的投資者包括藥明康德 (中國一家提供整合新藥研發服務平台的巨擎)、Peter Diamandis的 BOLD Capital以及 Pavilion Capital。[24]

注释

  1. ^ 台湾子公司名为“英科智能”

参考文献

  1. ^ 1.0 1.1 Gantz, Sarah. Insilico Medicine raises $10 million. [28 August 2017]. (原始内容存档于2018-08-10). 
  2. ^ Insilico Medicine launches a drug discovery platform ALS.AI. [28 August 2017]. (原始内容存档于2020-08-15) (英语). 
  3. ^ GlaxoSmithKline taps Baltimore’s Insilico for AI-based drug discovery | FierceBiotech. [28 August 2017]. (原始内容存档于2020-09-21) (英语). 
  4. ^ InSilico Medicine Company Profile | PitchBook. [28 August 2017] (英语). 
  5. ^ New partnership uses artificial intelligence methods to develop solutions for preventing early aging. 1 August 2017 [28 August 2017]. (原始内容存档于2021-01-18) (英语). 
  6. ^ Can artificial intelligence aid human age-reversal?. 12 August 2017 [28 August 2017]. (原始内容存档于2020-11-30). 
  7. ^ MolHack Hackathon. [10 August 2018]. (原始内容存档于2021-02-27). 
  8. ^ Kadurin, Artur. druGAN: An Advanced Generative Adversarial Autoencoder Model for de Novo Generation of New Molecules with Desired Molecular Properties in Silico: 3098–3104. 5 September 2017 [12 September 2017]. doi:10.1021/acs.molpharmaceut.7b00346. (原始内容存档于2019-07-19). 
  9. ^ Cox, Patrick. Here's How Pharma Is Using AI Deep Learning To Cure Aging. [12 September 2017]. (原始内容存档于2020-11-11) (英语). 
  10. ^ Putin, Evgeny; Asadulaev, Arip; Ivanenkov, Yan; Aladinskiy, Vladimir; Sanchez-Lengeling, Benjamin; Aspuru-Guzik, Alán; Zhavoronkov, Alex. Reinforced Adversarial Neural Computer for Molecular Design. Journal of Chemical Information and Modeling. 15 May 2018, 58 (6): 1194–1204. doi:10.1021/acs.jcim.7b00690. 
  11. ^ Ozerov, Ivan V.; Lezhnina, Ksenia V.; Izumchenko, Evgeny; Artemov, Artem V.; Medintsev, Sergey; Vanhaelen, Quentin; Aliper, Alexander; Vijg, Jan; Osipov, Andreyan N.; Labat, Ivan; West, Michael D.; Buzdin, Anton; Cantor, Charles R.; Nikolsky, Yuri; Borisov, Nikolay; Irincheeva, Irina; Khokhlovich, Edward; Sidransky, David; Camargo, Miguel Luiz; Zhavoronkov, Alex. In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development. Nature Communications: ncomms13427. 16 November 2016 [12 September 2017]. doi:10.1038/ncomms13427. (原始内容存档于2020-01-05) (英语). 
  12. ^ AI photo check exposes scale of diversity problem at top firms. New Scientist. [12 September 2017]. (原始内容存档于2021-01-22). 
  13. ^ Jarvis, Lisa M. GSK amps up AI with Insilico pact | August 28, 2017 Issue - Vol. 95 Issue 34 | Chemical & Engineering News. cen.acs.org. [12 September 2017]. (原始内容存档于2020-08-16). 
  14. ^ The first AI system for human embryonic state analysis is available for testing. EurekAlert!. [12 September 2017]. (原始内容存档于2018-10-30) (英语). 
  15. ^ First molecules discovered by next-generation artificial intelligence to be developed into drugs. EurekAlert!. [12 September 2017]. (原始内容存档于2020-10-20) (英语). 
  16. ^ Insilico Medicine's work on a ‘virtual human’ now has quantum computing behind it - Technical.ly Baltimore. Technical.ly Baltimore. 22 November 2016 [12 September 2017]. (原始内容存档于2020-11-23). 
  17. ^ Nvidia identifies the top 5 AI startups for social impact. VentureBeat. 23 April 2017 [28 August 2017]. (原始内容存档于2021-02-08). 
  18. ^ AgeHack@MLBootCamp: The first Eurasian hackathon on AI for longevity to launch. [28 August 2017]. (原始内容存档于2018-08-10). 
  19. ^ JHU alumni-run A-Level Capital to support AI-powered drug discovery at Insilico Medicine. [12 September 2017]. (原始内容存档于2018-08-10) (英语). 
  20. ^ Billionaire Jim Mellon invests in anti-ageing research firm - Pharmaphorum. 11 April 2017 [12 September 2017]. (原始内容存档于2020-11-27). 
  21. ^ AI Is Helping This Anti-Aging Startup Uncover Ways for You to Live a Longer, Healthier Life. 2 August 2017 [12 September 2017]. (原始内容存档于2019-06-18). 
  22. ^ Insilico, Juvenescence joint venture to develop AI-discovered molecules into new drugs. [28 August 2017]. (原始内容存档于2017-08-05). 
  23. ^ Insilico Medicine signs deal to advance use of AI in discovering new drugs - Technical.ly Baltimore. 28 July 2017 [28 August 2017]. (原始内容存档于2018-08-10). 
  24. ^ Zhavoronkov, Alex. The new era for AI-powered drug discovery and longevity biotechnology begins for Insilico following…. Medium. 11 June 2018 [10 August 2018]. (原始内容存档于2019-03-05).