聚氨丙基双胍

化合物

聚氨丙基双胍(英語:Polyaminopropyl biguanide,PAPB)是一种高分子聚合物,其结构单元包含两个胍基和三个亚甲基,为聚己双胍的同系物。PAPB具有一些抗菌活性,但抗菌效果远低于聚己双胍[1]。2024年3月,欧盟不再批准聚氨丙基双胍作为生物活性基材使用[2]

聚氨丙基双胍
别名 Polyamine-propyl-biguanidine
识别
缩写 PAPB
CAS号 133029-32-0  checkY
ChemSpider none
性质
化学式 (C5H11N5)n
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

名字争议

在某些领域,特别是化妆品领域,聚氨丙基双胍(PAPB)容易与聚己双胍(PHMB)混淆[3] [4]

参考文献

  1. ^ Rembe, J.-D., Fromm-Dornieden, C., Schafer, N., Böhm, J. K., & Stuermer, E. K. (2016). Comparing two polymeric biguanides: chemical distinction, antiseptic efficacy and cytotoxicity of polyaminopropyl biguanide and polyhexamethylene biguanide. *Journal of Medical Microbiology*, 65(8), 867
  2. ^ European Chemicals Agency (ECHA). (n.d.). List of approved active substances. Retrieved May 24, 2024, from https://echa.europa.eu/regulations/biocidal-products-regulation/approval-of-active-substances/list-of-approved-active-substances
  3. ^ Cosmetic Ingredient Review Expert Panel. Safety Assessment of Polyaminopropyl Biguanide as Used in Cosmetics (PDF). Cosmetic Ingredient Review (CIR). May 12, 2014 [2024-05-07]. 
  4. ^ Sukakul, Thanisorn; Dahlin, Jakob; Pontén, Ann; Antelmi, Annarita; Bruze, Magnus; Hamnerius, Nils; Hauksson, Inese; Isaksson, Marléne; Lejding, Tina; Svedman, Cecilia. Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide). Contact Dermatitis. 2021, 84 (5): 326–331. PMC 8048451 . PMID 33098110. doi:10.1111/cod.13728.