碘氰吲哚洛尔

碘氰吲哚洛尔(INN:Iodocyanopindolol)是一种与吲哚洛尔相关的药物,既可作为β1肾上腺素能受体拮抗剂,又可作为5-HT1A受体拮抗剂。其125I放射性标记衍生物已广泛用于绘制体内β肾上腺素能受体的分布图。[1]

碘氰吲哚洛尔
Skeletal formula of iodocyanopindolol
Space-filling model of the iodocyanopindolol molecule
臨床資料
ATC碼
  • 未分配
识别信息
  • (RS)-4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3-iodo-1H-indole-2-carbonitrile
CAS号85124-14-7  checkY
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C16H20IN3O2
摩尔质量413.26 g·mol−1
3D模型(JSmol英语JSmol
手性外消旋混合物
  • IC1=C(C#N)NC2=CC=CC(OCC(CNC(C)(C)C)O)=C21
  • InChI=1S/C16H20IN3O2/c1-16(2,3)19-8-10(21)9-22-13-6-4-5-11-14(13)15(17)12(7-18)20-11/h4-6,10,19-21H,8-9H2,1-3H3
  • Key:JBLUMBNIBNHRSO-UHFFFAOYSA-N

参考资料

  1. ^ Brodde OE, Karad K, Zerkowski HR, Rohm N, Reidemeister JC. Coexistence of beta 1- and beta 2-adrenoceptors in human right atrium. Direct identification by (+/-)-[125I]iodocyanopindolol binding. Circulation Research. 1983, 53 (6): 752–758. PMID 6139182. doi:10.1161/01.res.53.6.752 . 


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