潘卓华
潘卓华（1956年—）是一位美国华人神经科学家，光遗传学创始人[1]。
| 潘卓华 | |
|---|---|
| 出生 | 1956年 中国浙江省金华市浦江县 |
| 母校 | 中国科学技术大学 中国科学院 紐約州立大學水牛城分校 |
| 科学生涯 | |
| 研究领域 | 光遺傳學 |
| 机构 | 韦恩州立大学 |
生平
1956年出生于中国浙江浦江，父亲潘永鑑是金华市区老师，姨父郭根昌在金华一中担任高中班主任，1972年在姨父班上作插班生后转为正式。1977年恢复高考后考入中国科学技术大学，1982年考入中国科学院生物物理研究所，1984年获中国科学院生物物理所硕士。1986年考入美国纽约州立大学水牛城分校。1990年获纽约州立大学布法罗分校博士学位。1991年起任美国韦恩州立大学医学院解剖学和细胞生物学系教授。[2][3]
著作
- Pan, Z.-H. Differential expression of high- and two types of low-voltage-activated calcium currents in rod and cone bipolar cells of the rat retina. J. Neurophysiol. 83:513–527, 2000.
- Pan, Z.-H. and Hu, H.-J. Voltage-dependent Na+ currents in mammalian retinal cone bipolar cells. J. Neurophysiol. 84:2564–2571, 2000.
- Pan, Z.-H., Hu, H.-J., Perring, P., and Andrade, R. T-type Ca2+ channels mediate neurotransmitter release in retinal bipolar cells. Neuron 32:89–98, 2001
- Cui, J., Ma, Y.-P., Lipton, S.A., Pan Z.-H. Glycine receptors and glycinergic synaptic input at the axon terminals of mammalian retinal rod bipolar cells. J. Physiol. 553:895–909, 2003.
- Bi, A., Cui, J., Ma, Y.-P., Olshevskaya, E., Pu, M., Dizhoor, A.M., and Pan Z.-H. Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration. Neuron 50:23–33, 2006.
- Ivanova, E, Pan, Z.-H. Evaluation of virus mediated long-term expression of channelrhodopsin-2 in the mouse retina. Mol. Vision 15:1680–1689, 2009.
- Zhang, Y., Ivanova, E., Bi, A., and Pan, Z.-H. Ectopic expression of multiple microbial rhodopsins restores ON and OFF light responses in the retina after photoreceptor degeneration. J. Neurosci. 29:9186–96, 2009.
- Ivanova, E., Hwang, G.-S., Pan, Z.-H., and Troilo, D. Evaluation of AAV-mediated expression of chop2-GFP in the marmoset retina. Invest. Ophthalmol. Vis. Sci. 51:5288–5296, 2010.
- Wu, C., Ivanova, E., Cui, J., Lu Q. and Pan. Z.-H. Action potential generation at an AIS-like process in the axonless retinal AII amacrine cell. J. Neurosci. 31:14654–14659, 2011.
- Lu, Q., Ivanova, E., Ganjawala, H. T., and Pan, Z.-H. Cre-mediated recombination efficiency and transgene expression patterns of three retinal bipolar cell-expressing Cre transgenic mouse lines. Mol. Vision, 19:1310–1320, 2013
- Wu, C., Ivanova, E., Zhang, Y., Pan, Z.-H. AAV-mediated subcellular targeting of optogenetic tools in retinal ganglion cells. PloS One, 8(6):e66332, 2013.
- Pan, Z.-H., Ganjawala, T.H., Lu, Q., Ivanova, E., and Zhang, Z. ChR2 mutants at L132 and T159 with improved operational light sensitivity for vision restoration. PloS One, 9(6):e98924, 2014.
- Pan, Z.-H., Lu, Q., Bi, A., Dizhoor, A.M., and Abrams, G.W. Optogenetic approaches to restoring vision. Ann. Rev. Vision Sci. 1:185-210, 2015.
- Lu, Q., Ganjawala, H.T., Ivanova, E., Cheng , J.G., Troilo, D., and Pan, Z.-H. AAV-mediated transduction and targeting of retinal bipolar cells with improved mGluR6 promoters in rodents and primates. Gene Therapy, 23:680–9, 2016.
参考来源
- ^ 谢青松. 光遗传学创始人：浦江籍科学家潘卓华. 今日浦江. 2018-01-03 [2018-12-15]. （原始内容存档于2019-03-30）.
- ^ Vlasits, Anna. He may be the rightful inventor of neuroscience’s biggest breakthrough in decades. But you’ve never heard of him. STAT. 2016-09-01 [2018-12-15]. （原始内容存档于2021-03-26）.
- ^ Grens, Kerry. The History of Optogenetics Revised. The Scientist Magazine. 2016-09-01 [2018-12-15]. （原始内容存档于2020-11-09）.