利洛司酮

化合物

利洛司酮INN:liropristone;开发代号:ZK-98734ZK-734)是一种合成类甾体抗孕激素英语Antiprogestogen,具有额外的抗糖皮质激素英语Antiglucocorticoid活性。该药物由先灵公司英语Schering AG开发,于1985年获得专利。[1][2][3][4]它被描述为一种堕胎药英语abortifacient子宫内膜避孕药英语Hormonal contraception[1][4][5]该药物与米非司酮的不同之处仅在于其C17α侧链的结构,据说相比之下,其抗糖皮质激素活性大大降低。[6]

利洛司酮
臨床資料
其他名稱ZK-98734、ZK-734
识别信息
  • (8S,11R,13S,14S,17R)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-[(Z)-3-hydroxyprop-1-enyl]-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
CAS号97747-88-1
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C29H37NO3
摩尔质量447.62 g·mol−1
3D模型(JSmol英语JSmol
  • C[C@]12C[C@@H](C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@]2(/C=C\CO)O)C5=CC=C(C=C5)N(C)C
  • InChI=1S/C29H37NO3/c1-28-18-25(19-5-8-21(9-6-19)30(2)3)27-23-12-10-22(32)17-20(23)7-11-24(27)26(28)13-15-29(28,33)14-4-16-31/h4-6,8-9,14,17,24-26,31,33H,7,10-13,15-16,18H2,1-3H3/b14-4-/t24-,25+,26-,28-,29-/m0/s1
  • Key:RCOWGILQXUPXEW-FUSOFXSQSA-N

参考资料

  1. ^ 1.0 1.1 Elks J. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014: 733–. ISBN 978-1-4757-2085-3. 
  2. ^ Rao KA. Textbook of Gynaecology. Elsevier India. November 2009: 187–. ISBN 978-81-312-1526-5. 
  3. ^ Baird DT, Schütz G, Krattenmacher R. Organ-Selective Actions of Steroid Hormones. Springer Science & Business Media. 9 March 2013: 108–. ISBN 978-3-662-09153-1. 
  4. ^ 4.0 4.1 Milne GW. Drugs: Synonyms and Properties: Synonyms and Properties. Taylor & Francis. 8 May 2018: 23–. ISBN 978-1-351-78989-9. 
  5. ^ Deshpande H. Practical Management of Ovulation Induction. JP Medical Ltd. 12 February 2016: 29–. ISBN 978-93-5250-028-4. 
  6. ^ Van Look PF, Pérez-Palacios G, World Health Organization . Contraceptive research and development, 1984 to 1994: the road from Mexico City to Cairo and beyond. Oxford University Press. 1994: 169. ISBN 978-0-19-563630-7. [...] lilopristone, which differs from mifepristone only in the structure of the 17a side chain, is said to have a much reduced antiglucocorticoid activity (Neef et al., 1984). 

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