丙型肝炎病毒非结构蛋白3
非结构蛋白3(英語:Nonstructural protein 3,简称NS3),也称为p-70,是一种病毒非结构蛋白,是丙型肝炎病毒多蛋白的70 kDa裂解产物。它充当丝氨酸蛋白酶。[1][2]该蛋白的C端三分之二也充当解旋酶和核苷三磷酸酶。[3]NS3的前(N端)180个氨基酸具有作为NS2蛋白的辅助因子结构域的额外作用。[4]
![](http://images.weserv.nl/?url=//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/HCV_genome.png/220px-HCV_genome.png)
参见
参考资料
- ^ Hijikata, M.; et al. Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus. Proc. Natl. Acad. Sci. USA. 1993, 90 (22): 10773–10777. Bibcode:1993PNAS...9010773H. PMC 47860 . PMID 7504283. doi:10.1073/pnas.90.22.10773 .
- ^ Raney, Kevin D.; Sharma, Suresh D.; Moustafa, Ibrahim M.; Cameron, Craig E. Hepatitis C Virus Non-structural Protein 3 (HCV NS3): A Multifunctional Antiviral Target. Journal of Biological Chemistry. 2010, 285 (30): 22725–22731. PMC 2906261 . PMID 20457607. doi:10.1074/jbc.R110.125294 .
- ^ Stimulation of Hepatitis C Virus (HCV) Nonstructural Protein 3 (NS3) Helicase Activity by the NS3 Protease Domain and by HCV RNA-Dependent RNA Polymerase (页面存档备份,存于互联网档案馆) / J. Virol. July 2005 vol. 79 no. 14 8687-8697
- ^ Schregel, V; Jacobi, S; Penin, F; Tautz, N. Hepatitis C virus NS2 is a protease stimulated by cofactor domains in NS3. Proc Natl Acad Sci U S A. 2009, 106 (13): 5342–7. Bibcode:2009PNAS..106.5342S. PMC 2663979 . PMID 19282477. doi:10.1073/pnas.0810950106 .
- ^ NS3/4A Protease Inhibitors - DrugBank. [2024-03-03]. (原始内容存档于2017-11-07).
外部链接
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