ERG5

Sterol 22-desaturase
标识
生物	Saccharomyces cerevisiae S288c
符号	ERG5
可选符号	CYP61A1
Entrez	855029
RefSeq （mRNA）	NM_001182511.1
RefSeq （蛋白质）	NP_013728.1
UniProt	P54781
其他数据
EC number	1.14.19.41
染色体	XIII: 0.3 - 0.3 Mb

ERG5 或固醇-22-去饱和酶（英語：Sterol 22-desaturase）是真菌釀酒酵母（Saccharomyces cerevisiae）基因组中的一个涉及麦角固醇生物合成的细胞色素P450 酶，其CYP编号为CYP61A1^[1]，是釀酒酵母三种细胞色素P450基因之一，另外两种是CYP51F1和CYP56A1^[2]。ERG5可催化类固醇C17侧链上C22-C23位置脱氢形成双键，如麦角固醇生物合成中的5-脱氢表甾醇（也称为“麦角三烯醇”）转化为麦角四烯醇，之后麦角四烯醇的C24双键会被酶ERG4 加氢还原为麦角固醇^[3]。

参考文献

^ Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, et al. Global analysis of protein expression in yeast. Nature. October 2003, 425 (6959): 737–41. Bibcode:2003Natur.425..737G. PMID 14562106. doi:10.1038/nature02046.
^ Nelson DR. Cytochrome P450 diversity in the tree of life. Biochimica et Biophysica Acta. Proteins and Proteomics. January 2018, 1866 (1): 141–154. PMC 5681887  . PMID 28502748. doi:10.1016/j.bbapap.2017.05.003.
^ Kelly SL, Lamb DC, Baldwin BC, Corran AJ, Kelly DE. Characterization of Saccharomyces cerevisiae CYP61, sterol delta22-desaturase, and inhibition by azole antifungal agents. The Journal of Biological Chemistry. April 1997, 272 (15): 9986–8. PMID 9092539. doi:10.1074/JBC.272.15.9986.

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[1] Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, et al. Global analysis of protein expression in yeast. Nature. October 2003, 425 (6959): 737–41. Bibcode:2003Natur.425..737G. PMID 14562106. doi:10.1038/nature02046.

[2] Nelson DR. Cytochrome P450 diversity in the tree of life. Biochimica et Biophysica Acta. Proteins and Proteomics. January 2018, 1866 (1): 141–154. PMC 5681887  . PMID 28502748. doi:10.1016/j.bbapap.2017.05.003.

[3] Kelly SL, Lamb DC, Baldwin BC, Corran AJ, Kelly DE. Characterization of Saccharomyces cerevisiae CYP61, sterol delta22-desaturase, and inhibition by azole antifungal agents. The Journal of Biological Chemistry. April 1997, 272 (15): 9986–8. PMID 9092539. doi:10.1074/JBC.272.15.9986.

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