Comins试剂

化合物

Comins试剂是一种三氟甲磺酰化合物,可用于从相应的酮烯醇式合成三氟甲磺酸酯[1]

Comins试剂
识别
CAS号 145100-51-2  checkY
PubChem 388544
ChemSpider 344376
SMILES
 
  • O=S(=O)(N(c1ccc(Cl)cn1)S(=O)(=O)C(F)(F)F)C(F)(F)F
InChI
 
  • 1/C7H3ClF6N2O4S2/c8-4-1-2-5(15-3-4)16(21(17,18)6(9,10)11)22(19,20)7(12,13)14/h1-3H
InChIKey TUFGVZMNGTYAQD-UHFFFAOYAK
性质
化学式 C7H3ClF6N2O4S2
摩尔质量 392.68 g·mol−1
外观 白色固体
熔点 45 °C(318 K)
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。
Sample Reaction With Comin's Reagent
Sample Reaction With Comin's Reagent

它最早由Daniel Comins于1992年报道。[2] 三氟甲磺酸乙烯酯对于铃木反应来说是很有用的底物。[3]

参考文献

  1. ^ Mundy, Bradford P.; Ellerd, Michael G.; Favaloro, Frank G., Jr. Name Reactions and Reagents in Organic Synthesis 2nd. 2005. ISBN 0471228540. 
  2. ^ Comins, Daniel L.; Dehghani, Ali. Pyridine-Derived Triflating Reagents: An Improved Preparation of Vinyl Triflates from Metallo Enolates. Tetrahedron Letters. 1992, 33 (42): 6299–6302. doi:10.1016/S0040-4039(00)60957-7. 
  3. ^ Miyaura, Norio; Suzuki, Akira. Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds. Chemical Reviews. 1995, 95: 2457–2483. doi:10.1021/cr00039a007. 

外部链接