鸭嘴花碱

鸭嘴花碱(英语:Vasicine或peganine)是一种喹唑啉生物碱。它被发现于鸭嘴花Adhatoda vasica),并以此命名。它还存在于骆驼蓬中。[1]

鸭嘴花碱
IUPAC名
1,2,3,9-Tetrahydropyrrolo[2,1-b]quinazolin-3-ol
别名 Peganine
识别
CAS号 6159-56-4  checkY
PubChem 72610
SMILES
 
  • C1CN2CC3=CC=CC=C3N=C2C1O
性质
化学式 C11H12N2O
摩尔质量 188.23 g·mol−1
熔点 210 °C(483 K)
溶解性(丙酮、酒精、氯仿) 易溶
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

鸭嘴花碱也被和茶碱在体外和体内进行了比较。[2]鸭嘴花碱与类似物鸭嘴花碱酮的组合也被进行了研究。两种生物碱的组合(1:1)在体内和体外均显示出显着的支气管扩张活性。[3]这两种生物碱也是呼吸兴奋剂。[3]鸭嘴花碱具有心脏抑制作用,鸭嘴花碱酮是一种弱心脏兴奋剂;通过结合这两种生物碱可以使效果正常化。[3][4]据报道,鸭嘴花碱具有子宫兴奋作用。[4]

氨溴索是一种广泛使用的溶分泌剂,由鸭嘴花碱开发而成,可抑制人类肥大细胞嗜碱性粒细胞(过敏性炎症的主要效应物)分泌IgE依赖性介质。与鸭嘴花碱相比,氨溴索在降低嗜碱性粒细胞IL-4IL-13分泌方面表现出更大的效果。[5][6]

参考资料

  1. ^ Moloudizargari M, Mikaili P, Aghajanshakeri S, Asghari MH, Shayegh J. Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids. Pharmacogn Rev. July 2013, 7 (14): 199–212. PMC 3841998 . PMID 24347928. doi:10.4103/0973-7847.120524 . 
  2. ^ Nepali, Kunal; Sharma, Sahil; Ojha, Ritu; Dhar, Kanaya Lal. Vasicine and structurally related quinazolines. Medicinal Chemistry Research. 2012, 22 (1): 1–15. ISSN 1054-2523. S2CID 253636554. doi:10.1007/s00044-012-0002-5. 
  3. ^ 3.0 3.1 3.2 Avula, B.; et al. Quantitative determination of vasicine and vasicinone in Adhatoda vasica by high performance capillary electrophoresis (PDF). Die Pharmazie. 2008, 63 (1): 20–22. PMID 18271297. doi:10.1691/ph.2008.7175. 
  4. ^ 4.0 4.1 Rajani, M; Soni, S; Anandjiwala, Sheetal; Patel, G. Validation of different methods of preparation of Adhatoda vasica leaf juice by quantification of total alkaloids and vasicine. Indian Journal of Pharmaceutical Sciences. 2008, 70 (1): 36–42. ISSN 0250-474X. PMC 2852058 . PMID 20390078. doi:10.4103/0250-474X.40329 . 
  5. ^ Vasicine - an overview | ScienceDirect Topics. www.sciencedirect.com. [2024-03-03]. 
  6. ^ Gibbs, B. F. Differential modulation of IgE-dependent activation of human basophils by ambroxol and related secretolytic analogues. International Journal of Immunopathology and Pharmacology. 2009, 22 (4). ISSN 0394-6320. PMID 20074455. doi:10.1177/039463200902200407.