非诺特罗

化合物

非诺特罗(Fenoterol) 是一種用來擴張呼吸道β2肾上腺素受体激动药。非诺特罗 屬於拟交感神经药 β2 刺激劑和氣喘藥。

非诺特罗
臨床資料
AHFS/Drugs.comMicromedex详细消费者药物信息
给药途径Inhalation (MDI英语Metered-dose inhaler)
ATC碼
法律規範狀態
法律規範
藥物動力學數據
生物半衰期6.5小時左右 [1][2][3][4]
识别信息
  • (RR,SS)-5-(1-hydroxy-2-{[2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)benzene-1,3-diol
CAS号13392-18-2  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.205.960 編輯維基數據鏈接
化学信息
化学式C17H21NO4
摩尔质量303.35 g/mol
3D模型(JSmol英语JSmol
  • Oc1cc(cc(O)c1)C(O)CNC(C)Cc2ccc(O)cc2
  • InChI=1S/C17H21NO4/c1-11(6-12-2-4-14(19)5-3-12)18-10-17(22)13-7-15(20)9-16(21)8-13/h2-5,7-9,11,17-22H,6,10H2,1H3 checkY
  • Key:LSLYOANBFKQKPT-UHFFFAOYSA-N checkY

非诺特罗 由勃林格殷格翰製造和銷售,商品名稱為:Berotec N備勞喘)。製造商有時也會把非诺特罗與ipratropium混和後銷售,商品名稱為 Berodual N備喘全)。

醫學用途

非诺特罗 是短效的 β2刺激劑。當非诺特罗使用超過建議的醫療用劑量(每日最多只能吸入八劑、每劑量需間隔至少五分鐘,若氣喘狀況沒好轉,則再吸入第二劑[5])時,也會成為β1 受體英语Beta-1 adrenergic receptor刺激劑。

使用者可以於運動前吸入一劑,預防稍後因運動所誘發的氣喘(氣管痙攣)。[6]

副作用

已知曾有患者在急性氣喘發作時吸入了高達80劑的非诺特罗,最終因而死亡。當患者發現非诺特罗已經無法緩解氣喘時,應當停止吸入非诺特罗,並盡快就醫。[7][8]

 
Berotec
 
Berotec 備勞喘

參見

文獻來源

  1. ^ Fenoterol Hydrobromide Drug Information, Professional. Drugs.com. 1996-01-01 [2018-06-11]. (原始内容存档于2019-08-25). 
  2. ^ Fenoterol - Drug Monograph. DrugInfoSys.com. 2016-10-27 [2018-06-11]. (原始内容存档于2020-11-27). 
  3. ^ Berotec Inhalation Solution (Fenoterol HBr). RxMed.com. [2018-06-11]. (原始内容存档于2021-04-20). 
  4. ^ Svedmyr, Nils. Fenoterol: A Beta2-adrenergic Agonist for Use in Asthma; Pharmacology, Pharmacokinetics, Clinical Efficacy and Adverse Effects. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy (Wiley). 1985-05-06, 5 (3): 109–126. ISSN 0277-0008. doi:10.1002/j.1875-9114.1985.tb03409.x. 
  5. ^ Berotec N/Concise Prescribing Info/Full Prescribing info. 2018-02-28 [2018-02-28]. (原始内容存档于2020-11-23). Dosage / Direction for Use:
    Acute Asthma Episodes: 1 puff is sufficient for prompt symptom relief in most cases, if breathing has not noticeably improved after 5 minutes, a second dose may be taken, up to a maximum of 8 puffs per day. If an attack has not been relieved by 2 puffs, further puffs may be required. In this situation, patients should consult the doctor or the nearest hospital immediately. (See Precautions).
    Prophylaxis of Exercise Induced Asthma: 1-2 puffs prior to exercise, up to a maximum of 8 puffs per day.
    Bronchial Asthma and Other Conditions with Reversible Airways Narrowing: If repeated dosing is required, 1-2 puffs for each administration, up to a maximum of 8 puffs per day.
     
  6. ^ Management of acute exacerbations of asthma in adults. UpToDate. [2018-06-25]. (原始内容存档于2018-06-25). 
  7. ^ Beasley R, Pearce N, Crane J, Burgess C. Withdrawal of 非诺特罗 and the end of the New Zealand asthma mortality epidemic. International Archives of Allergy and Immunology. 1995, 107 (1-3): 325–7. PMID 7613161. doi:10.1159/000237016. 
  8. ^ Spitzer WO, Suissa S, Ernst P, et al. The use of beta-agonists and the risk of death and near death from asthma. The New England Journal of Medicine. February 1992, 326 (8): 501–6. PMID 1346340. doi:10.1056/NEJM199202203260801.