头孢噻呋

头孢噻呋
臨床資料
商品名（英语：Drug nomenclature）	Naxcel
AHFS/Drugs.com	国际药品名称
ATCvet碼	QJ01DD90 (WHO) QJ51DD90;
法律規範狀態
法律規範	歐：Rx-only;
识别信息
	IUPAC命名法 (6R,7R)-7-[ [(2Z)-2-(2-Amino-1,3-thiazol-4-yl)- 2-methoxyiminoacetyl]amino]-3-(furan-2- carbonylsulfanylmethyl)-8-oxo-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; ;
CAS号	80370-57-6
PubChem CID	6328657;
ChemSpider	4886668 ;
UNII	83JL932I1C;
KEGG	D07657 ;
ChEMBL	ChEMBL222913 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID7046702 ;
化学信息
化学式	C19H17N5O7S3
摩尔质量	523.55 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)/c3nc(sc3)N)CSC(=O)c4occc4)C(=O)O;
	InChI InChI=1S/C19H17N5O7S3/c1-30-23-11(9-7-34-19(20)21-9)14(25)22-12-15(26)24-13(17(27)28)8(5-32-16(12)24)6-33-18(29)10-3-2-4-31-10/h2-4,7,12,16H,5-6H2,1H3,(H2,20,21)(H,22,25)(H,27,28)/b23-11-/t12-,16-/m1/s1 ; Key:ZBHXIWJRIFEVQY-IHMPYVIRSA-N ;

头孢噻呋（英语：Ceftiofur）是一种头孢菌素类抗生素（第三代），获准用作兽药。它于1987年首次被描述。^[1]它由制药公司硕腾销售，商品名包括Excenel、^[2]Naxcel和Excede，也是该公司Spectramast LC（泌乳牛配方）和Spectramast DC（干奶牛配方）产品中的活性成分。

它对抗生素耐药酶β-内酰胺酶具有抗性，并且对革兰氏阳性菌和革兰氏阴性菌均具有活性。据报道，大肠杆菌菌株对头孢噻呋具有抗药性。^[3]

代谢物去呋喃酰头孢噻呋也具有抗生素活性。^[4]这两种化合物一同被测量，以检测牛奶中的抗生素活性（与其他抗生素一起）。^[5]

参考资料

^ Yancey RJ, Kinney ML, Roberts BJ, Goodenough KR, Hamel JC, Ford CW. Ceftiofur sodium, a broad-spectrum cephalosporin: evaluation in vitro and in vivo in mice. Am. J. Vet. Res. 1987, 48 (7): 1050–3. PMID 3631686.
^ Pfizer Animal Health Dairy Information on Products and Solutions. [2007-11-20]. （原始内容存档于2007-10-13）.
^ Donaldson SC, Straley BA, Hegde NV, Sawant AA, DebRoy C, Jayarao BM. Molecular epidemiology of ceftiofur-resistant Escherichia coli isolates from dairy calves. Appl. Environ. Microbiol. 2006, 72 (6): 3940–8. PMC 1489609  . PMID 16751500. doi:10.1128/AEM.02770-05.
^ Salmon SA, Watts JL, Yancey RJ. In vitro activity of ceftiofur and its primary metabolite, desfuroylceftiofur, against organisms of veterinary importance. Journal of Veterinary Diagnostic Investigation. July 1996, 8 (3): 332–336. PMID 8844576. doi:10.1177/104063879600800309  .
^ BetaStar Plus / For beta-lactam antibiotics / Product information sheet (PDF). Neogen. [9 September 2014]. （原始内容存档 (PDF)于2016-03-04）.

外部链接

Ceftiofur. Drug Information Portal. U.S. National Library of Medicine.
Ceftiofur Hydrochloride. Drug Information Portal. U.S. National Library of Medicine.

这是一篇与合成抗生素相关小作品。您可以通过编辑或修订扩充其内容。

[1] Yancey RJ, Kinney ML, Roberts BJ, Goodenough KR, Hamel JC, Ford CW. Ceftiofur sodium, a broad-spectrum cephalosporin: evaluation in vitro and in vivo in mice. Am. J. Vet. Res. 1987, 48 (7): 1050–3. PMID 3631686.

[2] Pfizer Animal Health Dairy Information on Products and Solutions. [2007-11-20]. （原始内容存档于2007-10-13）.

[3] Donaldson SC, Straley BA, Hegde NV, Sawant AA, DebRoy C, Jayarao BM. Molecular epidemiology of ceftiofur-resistant Escherichia coli isolates from dairy calves. Appl. Environ. Microbiol. 2006, 72 (6): 3940–8. PMC 1489609  . PMID 16751500. doi:10.1128/AEM.02770-05.

[4] Salmon SA, Watts JL, Yancey RJ. In vitro activity of ceftiofur and its primary metabolite, desfuroylceftiofur, against organisms of veterinary importance. Journal of Veterinary Diagnostic Investigation. July 1996, 8 (3): 332–336. PMID 8844576. doi:10.1177/104063879600800309  .

[5] BetaStar Plus / For beta-lactam antibiotics / Product information sheet (PDF). Neogen. [9 September 2014]. （原始内容存档 (PDF)于2016-03-04）.

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